Endocrine Abstracts

Introduction: There is a lack of epidemiological data on the distribution of haptoglobin and C677T of MTHFR polymorphisms in Caucasians type 2 diabetic patients. The contribution of these two genetic factors to hyperhomocysteinemia and hypercysteinemia can be useful to prevent cardiovascular events and to reduce public health costs. The aim of this study is to evaluate the contribution of haptoglobin and C677T polymorphisms for hyperhomocysteinemia and hypercysteinemia in Port...

Introduction: Type 2 diabetes mellitus have been associated with excessive production of reactive oxygen species. Glutathione S-transferase (GST) polymorphisms result in decreased or absent enzyme activity and altered oxidative stress. Meta-analyses have indicated that deletion of either GSTM1 or GSTT1 is associated with a significant increased risk of coronary heart disease. The aim of this study was to evaluated if ascorbic acid (AA) plasma levels differ by GST genotype in d...